ASF1B

Across TCGA patient cohorts, ASF1B mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASF1B-associated genes across cancer lineages are A-Raf_pS299, Ku80, and NF2. Each is linked with ASF1B in more than 1 cancer types. Because this analysis shows association rather than direction, both ASF1B-to-partner and partner-to-ASF1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by ASF1B-low versus ASF1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASF1B→partner) and Y-score (partner→ASF1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.173	-3.459	.003	.005	3	1
UCEC	Ku80 →	+0.327	+3.009	.005	.019	3	1
UCEC	NF2 →	+0.249	+3.459	.022	.005	3	1
UCEC	p62 Lck ligand →	+0.427	+3.009	.008	.019	3	1
UCEC	Tuberin →	+0.389	+2.331	.004	.019	3	1
UCEC	4E-BP1 →	+0.317	+3.459	.019	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

A-Raf_pS299 by ASF1B expression — UCEC

Explore this box plot interactively →