ASF1B

Across TCGA cell cohorts, ASF1B RNA expression is significantly associated with the go_rna of many other GO terms, with 4,436 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ASF1B-associated GO terms across cancer lineages are Regulation of DNA-templated DNA replication, Mitotic chromosome condensation, and Regulation of mitotic sister chromatid separation. Each is linked with ASF1B in more than 18 cancer types. Because this analysis shows association rather than direction, both ASF1B-to-partner and partner-to-ASF1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA-templated DNA replication grouped by ASF1B-low versus ASF1B-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ASF1B→partner) and Y-score (partner→ASF1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of DNA-templated DNA replication →	+0.141	+1.868	<.001	<.001	3	19
OESOPHAGUS	Mitotic chromosome condensation →	+0.232	+1.191	.001	.002	3	18
UPPER_AERODIGESTIVE_TRACT	Regulation of mitotic sister chromatid separation →	+0.159	+1.587	.001	.001	3	18
PANCREAS	Positive regulation of chromosome condensation →	+0.225	+1.398	<.001	<.001	3	18
KIDNEY	Immunoglobulin heavy chain V-D-J recombination →	+0.176	+1.254	.001	<.001	3	18
BONE	DNA replication checkpoint signaling →	+0.248	+1.440	<.001	.006	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,436 associations by consensus.

Regulation of DNA-templated DNA replication by ASF1B expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →