Across TCGA patient cohorts, ASCL4 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,012 significant associations in total. STAD shows the largest number of these associations.

The most reproducible ASCL4-associated GO terms across cancer lineages are Fc receptor mediated stimulatory signaling pathway, Peptide antigen assembly with MHC protein complex, and Positive regulation of CD4-positive, alpha-beta T cell differentiation. Each is linked with ASCL4 in more than 15 cancer types. Because this analysis shows association rather than direction, both ASCL4-to-partner and partner-to-ASCL4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ASCL4→partner) and Y-score (partner→ASCL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Fc receptor mediated stimulatory signaling pathway →	+0.098	+0.047	<.001	.002	2	16
SARC	Peptide antigen assembly with MHC protein complex →	+0.090	+0.047	<.001	<.001	3	15
STAD	Positive regulation of CD4-positive, alpha-beta T cell differentiation →	+0.048	+0.039	<.001	<.001	3	15
STAD	Positive regulation of apoptotic signaling pathway →	+0.049	+0.046	<.001	<.001	3	14
STAD	Mature B cell differentiation →	+0.063	+0.043	<.001	<.001	3	14
STAD	Peptide antigen assembly with MHC class II protein complex →	+0.114	+0.054	<.001	.005	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,012 associations by consensus.

Exploration

ASCL4 survival (RNA) · tumor vs normal (RNA) · all ASCL4 data types