Across TCGA patient cohorts, ASCL4 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASCL4-associated genes across cancer lineages are MEK1, eIF4G, and FOXO3a_pS318_S321. Each is linked with ASCL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASCL4-to-partner and partner-to-ASCL4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASCL4→partner) and Y-score (partner→ASCL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.323	+1.807	.032	.027	3	2
UCEC	eIF4G →	+0.321	+3.169	.012	.018	3	1
UCEC	FOXO3a_pS318_S321 →	-0.144	-3.321	.005	.009	3	1
UCEC	ACC1 →	+0.329	+2.820	.028	.035	3	1
UCEC	GSK3-a-b →	+0.110	+1.807	.048	.027	3	1
UCEC	JNK2 →	+0.262	+3.196	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Exploration

ASCL4 survival (RNA) · tumor vs normal (RNA) · all ASCL4 data types