ASCL3

Across TCGA patient cohorts, ASCL3 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,925 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible ASCL3-associated GO terms across cancer lineages are Epigenetic regulation of gene expression, Protein polyubiquitination, and Cellular senescence. Each is linked with ASCL3 in more than 25 cancer types. Because this analysis shows association rather than direction, both ASCL3-to-partner and partner-to-ASCL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epigenetic regulation of gene expression grouped by ASCL3-low versus ASCL3-high in SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ASCL3→partner) and Y-score (partner→ASCL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Epigenetic regulation of gene expression →	+0.089	+0.427	<.001	.001	3	26
ESCA	Protein polyubiquitination →	+0.078	+0.339	<.001	<.001	3	24
STAD	Cellular senescence →	+0.064	+0.183	<.001	<.001	3	23
SCLC	Obsolete histone modification →	+0.101	+0.531	<.001	<.001	3	23
STAD	Microtubule polymerization or depolymerization →	+0.060	+0.166	<.001	<.001	3	23
STAD	Regulation of microtubule-based process →	+0.050	+0.195	<.001	<.001	3	23

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,925 associations by consensus.

Epigenetic regulation of gene expression by ASCL3 expression — SCLC

Explore this box plot interactively →