ASCL3

Across TCGA cell cohorts, ASCL3 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,951 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ASCL3-associated GO terms across cancer lineages are Negative regulation of calcium ion export across plasma membrane, Microtubule polymerization, and Positive regulation of intracellular steroid hormone receptor signaling pathway. Each is linked with ASCL3 in more than 10 cancer types. Because this analysis shows association rather than direction, both ASCL3-to-partner and partner-to-ASCL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of calcium ion export across plasma membrane grouped by ASCL3-low versus ASCL3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ASCL3→partner) and Y-score (partner→ASCL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of calcium ion export across plasma membrane →	+0.066	+0.188	<.001	.002	3	11
BLOOD_Leukemia	Microtubule polymerization →	+0.105	+0.207	<.001	<.001	3	11
SOFT_TISSUE	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.128	+0.108	<.001	<.001	3	9
BONE	Negative regulation of mRNA splicing, via spliceosome →	+0.075	+0.173	.003	.006	3	9
BONE	Negative regulation of mRNA processing →	+0.070	+0.173	.005	.006	3	9
OVARY	mRNA transport →	+0.056	+0.096	.001	.006	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,951 associations by consensus.

Negative regulation of calcium ion export across plasma membrane by ASCL3 expression — BONE

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