Across TCGA patient cohorts, ASCL2 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,341 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ASCL2-associated proteins across cancer lineages are ASCL2_S142, PPP2R1B, and ASCL2_S28. Each is linked with ASCL2 in more than 4 cancer types. Because this analysis shows association rather than direction, both ASCL2-to-partner and partner-to-ASCL2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ASCL2→partner) and Y-score (partner→ASCL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASCL2_S142 →	+1.472	+1.787	<.001	<.001	3	5
LSCC	PPP2R1B →	+0.476	+0.848	<.001	.003	3	4
LSCC	ASCL2_S28 →	+1.571	+1.498	<.001	<.001	3	4
LSCC	HSPA14 →	+0.385	+1.167	<.001	<.001	3	4
CCRCC	PIK3AP1 →	+0.448	+0.628	<.001	<.001	3	4
GBM	RASAL3_S819 →	+0.818	+0.629	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,341 associations by consensus.

Exploration

ASCL2 survival (RNA) · tumor vs normal (RNA) · all ASCL2 data types