Across TCGA patient cohorts, ASCL2 mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASCL2-associated genes across cancer lineages are MIR1263, MIR1283-1, and MIR1179. Each is linked with ASCL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASCL2-to-partner and partner-to-ASCL2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASCL2→partner) and Y-score (partner→ASCL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR1263 →	+1.494	+7.741	<.001	.009	3	1
COAD	MIR1283-1 →	+0.726	+7.741	<.001	.009	3	1
COAD	MIR1179 →	+1.171	+7.741	<.001	.009	3	1
COAD	MTATP6P30 →	+0.147	+7.741	<.001	.009	3	1
COAD	RNU7-176P →	+0.537	+7.741	<.001	.009	3	1
COAD	MBD3L3 →	+0.129	+7.741	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Exploration

ASCL2 survival (RNA) · tumor vs normal (RNA) · all ASCL2 data types