ASCL1

Across TCGA patient cohorts, ASCL1 protein abundance is significantly associated with the RNA expression of many other genes, with 3,669 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ASCL1-associated genes across cancer lineages are LGALS2, SDR39U1, and RBM23. Each is linked with ASCL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASCL1-to-partner and partner-to-ASCL1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ASCL1 versus LGALS2 in GBM, with a Pearson correlation of 0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASCL1→partner) and Y-score (partner→ASCL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LGALS2 →	+0.614	+0.727	.005	.005	3	1
GBM	SDR39U1 →	+0.420	+0.708	.004	.001	3	1
GBM	RBM23 →	+0.512	+0.846	<.001	<.001	3	1
GBM	AP4S1 →	+0.552	+0.821	.004	.007	3	1
GBM	VCPKMT →	+0.454	+0.626	.001	.002	3	1
GBM	SOS2 →	+0.428	+0.889	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,669 associations by consensus.

ASCL1 vs LGALS2 — GBM

Explore this scatter interactively →