ASCL1

Across TCGA patient cohorts, ASCL1 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASCL1-associated genes across cancer lineages are Annexin-1, Shc_pY317, and eEF2. Each is linked with ASCL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASCL1-to-partner and partner-to-ASCL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by ASCL1-low versus ASCL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASCL1→partner) and Y-score (partner→ASCL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.694	+2.189	.003	.034	3	2
UCEC	Shc_pY317 →	-0.270	-3.169	<.001	.018	3	2
UCEC	eEF2 →	+0.466	+2.000	.003	.032	3	1
UCEC	FASN →	+0.496	+2.700	.005	.006	3	1
UCEC	FOXO3a_pS318_S321 →	-0.172	-3.690	.002	.001	3	1
UCEC	GAPDH →	+0.593	+3.169	.014	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Annexin-1 by ASCL1 expression — UCEC

Explore this box plot interactively →