ASCL1

Across TCGA cell cohorts, ASCL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,805 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible ASCL1-associated GO terms across cancer lineages are Noradrenergic neuron development, Regulation of cytoplasmic mRNA processing body assembly, and Establishment of RNA localization. Each is linked with ASCL1 in more than 9 cancer types. Because this analysis shows association rather than direction, both ASCL1-to-partner and partner-to-ASCL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Noradrenergic neuron development grouped by ASCL1-low versus ASCL1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ASCL1→partner) and Y-score (partner→ASCL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Noradrenergic neuron development →	+1.188	+6.127	<.001	<.001	3	10
LUNG_SCLC	Regulation of cytoplasmic mRNA processing body assembly →	+0.158	+5.389	<.001	<.001	3	6
CNS	Establishment of RNA localization →	+0.077	+0.178	<.001	.001	3	6
CNS	RNA localization →	+0.073	+0.175	<.001	.002	3	6
OESOPHAGUS	Regulation of DNA-templated transcription elongation →	+0.068	+0.412	.001	.004	3	6
OESOPHAGUS	Light absorption →	-0.140	-0.306	.008	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,805 associations by consensus.

Noradrenergic neuron development by ASCL1 expression — LUNG_SCLC

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