ASCL1

Across TCGA cell cohorts, ASCL1 mutation is significantly associated with the mutation status of many other genes, with 3,989 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ASCL1-associated genes across cancer lineages are DENND1A, IGF1R, and RIMS2. Each is linked with ASCL1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ASCL1-to-partner and partner-to-ASCL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DENND1A grouped by ASCL1-low versus ASCL1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASCL1→partner) and Y-score (partner→ASCL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	DENND1A →	+6.044	+6.044	.001	.001	1	4
LARGE_INTESTINE	IGF1R →	+2.974	+4.643	<.001	<.001	1	4
BLOOD_Leukemia	RIMS2 →	+3.157	+4.665	.003	.003	1	4
CNS	SRGAP1 →	+5.044	+5.614	.003	.003	1	4
CNS	SLC26A5 →	+6.044	+6.044	.001	.001	1	4
BLOOD_Leukemia	EPHA6 →	+3.479	+4.932	.002	.002	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,989 associations by consensus.

DENND1A by ASCL1 expression — CNS

Explore this box plot interactively →