ASCC2

Across TCGA patient cohorts, ASCC2 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASCC2-associated genes across cancer lineages are JNK_pT183_Y185, mTOR_pS2448, and PDK1_pS241. Each is linked with ASCC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASCC2-to-partner and partner-to-ASCC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by ASCC2-low versus ASCC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASCC2→partner) and Y-score (partner→ASCC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.203	-2.087	<.001	.005	3	2
UCEC	mTOR_pS2448 →	-0.155	-2.687	.003	.005	3	2
UCEC	PDK1_pS241 →	+0.160	+2.026	.009	.016	3	2
UCEC	14-3-3_beta →	-0.119	-3.780	<.001	<.001	3	1
UCEC	eEF2 →	+0.358	+2.000	.005	.029	3	1
UCEC	EGFR_pY1068 →	-0.294	-2.807	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

JNK_pT183_Y185 by ASCC2 expression — UCEC

Explore this box plot interactively →