ASCC1

Across TCGA patient cohorts, ASCC1 mutation is significantly associated with the RNA expression of many other genes, with 1,103 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASCC1-associated genes across cancer lineages are PRAMEF13, GEMIN7P1, and LINC01148. Each is linked with ASCC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASCC1-to-partner and partner-to-ASCC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF13 grouped by ASCC1-low versus ASCC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASCC1→partner) and Y-score (partner→ASCC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRAMEF13 →	+0.047	+4.284	<.001	<.001	3	2
LUSC	GEMIN7P1 →	+0.130	+4.792	<.001	.006	3	2
UCEC	LINC01148 →	+0.060	+2.854	.006	.001	3	2
UCEC	MAPK1 →	+0.614	+3.202	.007	.009	3	1
UCEC	CRYBB2P1 →	+0.511	+3.329	.009	.005	3	1
UCEC	SRRD →	+0.670	+3.212	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,103 associations by consensus.

PRAMEF13 by ASCC1 expression — UCEC

Explore this box plot interactively →