ASCC1

Across TCGA patient cohorts, ASCC1 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASCC1-associated genes across cancer lineages are MEK1, Annexin_VII, and Tuberin_pT1462. Each is linked with ASCC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASCC1-to-partner and partner-to-ASCC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ASCC1-low versus ASCC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASCC1→partner) and Y-score (partner→ASCC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.406	+3.321	.027	.010	3	1
UCEC	Annexin_VII →	-0.162	-2.321	.020	.035	3	1
UCEC	Tuberin_pT1462 →	+0.390	+3.179	<.001	.010	3	1
UCEC	ASNS →	+0.641	+2.321	<.001	.035	3	1
UCEC	CD49b →	-0.283	-2.308	.047	.036	3	1
UCEC	eIF4G →	+0.403	+2.321	.009	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

MEK1 by ASCC1 expression — UCEC

Explore this box plot interactively →