ASB8

Across TCGA patient cohorts, ASB8 mutation is significantly associated with the RNA expression of many other genes, with 111 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASB8-associated genes across cancer lineages are TRAJ34, RNA5SP86, and MIR6842. Each is linked with ASB8 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASB8-to-partner and partner-to-ASB8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ34 grouped by ASB8-low versus ASB8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASB8→partner) and Y-score (partner→ASB8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRAJ34 →	+0.842	+2.797	<.001	.005	3	2
UCEC	RNA5SP86 →	+0.527	+3.299	<.001	.006	3	2
COAD	MIR6842 →	+0.882	+5.693	<.001	.003	3	2
BLCA	POTED →	+0.023	+4.859	<.001	.004	3	1
BLCA	RNA5SP427 →	+0.180	+4.314	<.001	.009	3	1
BLCA	RNU6-571P →	+0.338	+4.213	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 111 associations by consensus.

TRAJ34 by ASB8 expression — UCEC

Explore this box plot interactively →