Across TCGA patient cohorts, ASB7 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASB7-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and eIF4E. Each is linked with ASB7 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASB7-to-partner and partner-to-ASB7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASB7→partner) and Y-score (partner→ASB7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.113	-2.780	.001	.003	3	1
UCEC	EGFR_pY1068 →	-0.231	-2.321	.009	.005	3	1
UCEC	eIF4E →	+0.209	+3.598	.005	.001	3	1
UCEC	A-Raf_pS299 →	-0.099	-2.222	.019	.010	3	1
UCEC	ERK2 →	+0.185	+3.321	.006	.009	3	1
UCEC	FOXO3a_pS318_S321 →	-0.111	-1.990	.011	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Exploration

ASB7 survival (RNA) · tumor vs normal (RNA) · all ASB7 data types