ASB6

Across TCGA patient cohorts, ASB6 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASB6-associated genes across cancer lineages are JNK2, S6_pS240_S244, and c-Kit. Each is linked with ASB6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASB6-to-partner and partner-to-ASB6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by ASB6-low versus ASB6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASB6→partner) and Y-score (partner→ASB6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.253	+3.196	.003	.009	3	2
UCEC	S6_pS240_S244 →	+0.500	+2.820	.004	.035	3	2
UCEC	c-Kit →	-0.223	-2.115	.028	.019	3	2
UCEC	eIF4E →	+0.245	+3.906	.007	<.001	3	1
UCEC	eIF4G →	+0.269	+2.115	.047	.019	3	1
UCEC	A-Raf_pS299 →	-0.113	-3.000	.030	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

JNK2 by ASB6 expression — UCEC

Explore this box plot interactively →