ASB6

Across TCGA cell cohorts, ASB6 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ASB6-associated genes across cancer lineages are KLRF1, ADH1B, and DAZ4. Each is linked with ASB6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASB6-to-partner and partner-to-ASB6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLRF1 grouped by ASB6-low versus ASB6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASB6→partner) and Y-score (partner→ASB6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KLRF1 →	+0.663	+2.817	.003	.007	3	1
LARGE_INTESTINE	ADH1B →	+0.053	+2.989	<.001	.003	3	1
LARGE_INTESTINE	DAZ4 →	+0.123	+3.240	.004	.004	3	1
LARGE_INTESTINE	DAZ2 →	+0.127	+3.678	.004	.001	3	1
LARGE_INTESTINE	TMSB4Y →	+1.415	+2.819	<.001	.006	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

KLRF1 by ASB6 expression — LARGE_INTESTINE

Explore this box plot interactively →