ASB5

Across TCGA patient cohorts, ASB5 mutation is significantly associated with the RNA expression of many other genes, with 2,816 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASB5-associated genes across cancer lineages are MCU, FOXRED2, and RPP25. Each is linked with ASB5 in more than 2 cancer types. Because this analysis shows association rather than direction, both ASB5-to-partner and partner-to-ASB5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MCU grouped by ASB5-low versus ASB5-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASB5→partner) and Y-score (partner→ASB5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MCU →	+0.446	+3.330	.001	.005	3	3
UCEC	FOXRED2 →	+0.600	+2.295	<.001	<.001	3	3
COAD	RPP25 →	+0.633	+3.341	.003	.005	3	3
UCEC	ARL1 →	+0.423	+3.743	<.001	<.001	3	3
UCEC	KLHL3 →	-0.557	-1.938	<.001	.001	3	3
UCEC	FANCC →	+0.372	+3.939	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,816 associations by consensus.

MCU by ASB5 expression — LUSC

Explore this box plot interactively →