ASB5

Across TCGA patient cohorts, ASB5 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASB5-associated genes across cancer lineages are ASNS, MYH11, and ACC1. Each is linked with ASB5 in more than 3 cancer types. Because this analysis shows association rather than direction, both ASB5-to-partner and partner-to-ASB5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by ASB5-low versus ASB5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASB5→partner) and Y-score (partner→ASB5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+1.021	+3.178	<.001	.010	3	4
SKCM	MYH11 →	-0.840	-3.169	.035	.018	3	3
SKCM	ACC1 →	+0.394	+3.012	.005	.018	3	2
UCEC	Notch1 →	+0.128	+1.750	.013	.049	3	2
UCEC	Rab11 →	-0.116	-1.847	.030	.008	3	2
UCEC	TFRC →	+0.405	+2.999	.037	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

ASNS by ASB5 expression — COAD

Explore this box plot interactively →