ASB5

Across TCGA cell cohorts, ASB5 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible ASB5-associated genes across cancer lineages are OR4A47, IL36A, and OR7G3. Each is linked with ASB5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASB5-to-partner and partner-to-ASB5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4A47 grouped by ASB5-low versus ASB5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASB5→partner) and Y-score (partner→ASB5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR4A47 →	+0.018	+4.437	<.001	.004	3	2
LUNG_SCLC	IL36A →	+0.026	+5.643	<.001	.002	3	1
LUNG_SCLC	OR7G3 →	+0.063	+5.643	<.001	.002	3	1
LUNG_SCLC	FFAR3 →	+0.047	+5.029	<.001	.006	3	1
LUNG_SCLC	FAM25A →	+0.186	+5.643	<.001	.002	3	1
LUNG_SCLC	OR4D10 →	+0.022	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

OR4A47 by ASB5 expression — LARGE_INTESTINE

Explore this box plot interactively →