ASB4

Across TCGA cell cohorts, ASB4 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ASB4-associated genes across cancer lineages are OR11H6, CYP2A13, and ASPN. Each is linked with ASB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASB4-to-partner and partner-to-ASB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR11H6 grouped by ASB4-low versus ASB4-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASB4→partner) and Y-score (partner→ASB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR11H6 →	+0.026	+4.321	<.001	.009	3	1
CNS	CYP2A13 →	+0.043	+5.044	<.001	.001	3	1
LARGE_INTESTINE	ASPN →	+0.054	+3.426	<.001	.007	3	1
LARGE_INTESTINE	C6orf118 →	+0.154	+3.115	<.001	.004	3	1
LARGE_INTESTINE	DEFA4 →	+0.022	+3.700	<.001	.009	3	1
LARGE_INTESTINE	C9orf153 →	+0.236	+3.497	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

OR11H6 by ASB4 expression — CNS

Explore this box plot interactively →