ASB3

Across TCGA patient cohorts, ASB3 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASB3-associated genes across cancer lineages are 14-3-3_beta, A-Raf_pS299, and GSK-3a-b_pS21_S9. Each is linked with ASB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASB3-to-partner and partner-to-ASB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by ASB3-low versus ASB3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASB3→partner) and Y-score (partner→ASB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.097	-2.295	.011	.033	3	1
UCEC	A-Raf_pS299 →	-0.101	-2.115	.028	.017	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.357	+2.087	.029	.005	3	1
UCEC	Ku80 →	+0.212	+1.691	.019	.014	3	1
UCEC	MEK1 →	+0.492	+2.807	<.001	.003	3	1
UCEC	Notch1 →	+0.166	+2.472	.002	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

14-3-3_beta by ASB3 expression — UCEC

Explore this box plot interactively →