ASB2

Across TCGA patient cohorts, ASB2 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASB2-associated genes across cancer lineages are eIF4E, A-Raf_pS299, and ERK2. Each is linked with ASB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASB2-to-partner and partner-to-ASB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ASB2-low versus ASB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASB2→partner) and Y-score (partner→ASB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.187	+2.713	.010	.003	3	1
UCEC	A-Raf_pS299 →	-0.127	-2.000	.002	.009	3	1
UCEC	ERK2 →	+0.149	+3.584	.026	.002	3	1
UCEC	JNK2 →	+0.177	+1.594	.010	.042	3	1
UCEC	Ku80 →	+0.229	+1.688	.005	.013	3	1
UCEC	MEK1 →	+0.477	+2.459	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

eIF4E by ASB2 expression — UCEC

Explore this box plot interactively →