ASB2

Across TCGA cell cohorts, ASB2 mutation is significantly associated with the RNA expression of many other genes, with 57 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ASB2-associated genes across cancer lineages are MSTN, USP17L8, and PDHA2. Each is linked with ASB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASB2-to-partner and partner-to-ASB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSTN grouped by ASB2-low versus ASB2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASB2→partner) and Y-score (partner→ASB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MSTN →	+0.280	+3.383	<.001	.007	3	2
SOFT_TISSUE	USP17L8 →	+0.010	+4.977	<.001	.002	3	1
LUNG_SCLC	PDHA2 →	+0.026	+5.029	<.001	.006	3	1
LUNG_SCLC	OR8B12 →	+0.021	+5.029	.001	.006	3	1
LUNG_NSCLC_LUAD	OR4K1 →	+0.022	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	KRTAP5-11 →	+0.066	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

MSTN by ASB2 expression — BLOOD_Leukemia

Explore this box plot interactively →