ASB18

Across TCGA patient cohorts, ASB18 mutation is significantly associated with the RNA expression of many other genes, with 491 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASB18-associated genes across cancer lineages are RNU6-633P, RNU6-975P, and RNU1-28P. Each is linked with ASB18 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASB18-to-partner and partner-to-ASB18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-633P grouped by ASB18-low versus ASB18-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASB18→partner) and Y-score (partner→ASB18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-633P →	+1.023	+4.374	<.001	.002	3	2
SKCM	RNU6-975P →	+0.528	+3.913	<.001	.006	3	2
UCEC	RNU1-28P →	+0.259	+3.025	.001	.002	3	2
SCLC	SLC1A2 →	+1.445	+4.329	<.001	.006	3	1
SCLC	IFNA8 →	+0.092	+5.228	<.001	.002	3	1
SCLC	OR51V1 →	+0.074	+4.624	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 491 associations by consensus.

RNU6-633P by ASB18 expression — COAD

Explore this box plot interactively →