ASB18

Across TCGA cell cohorts, ASB18 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ASB18-associated genes across cancer lineages are SIGLEC12, OPN1MW3, and IL9. Each is linked with ASB18 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASB18-to-partner and partner-to-ASB18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIGLEC12 grouped by ASB18-low versus ASB18-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASB18→partner) and Y-score (partner→ASB18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SIGLEC12 →	+0.042	+4.044	<.001	.009	3	1
LUNG_SCLC	OPN1MW3 →	+0.010	+4.643	<.001	.004	3	1
LUNG_NSCLC_LUAD	IL9 →	+0.040	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	KRTAP17-1 →	+0.028	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	GPX6 →	+0.116	+4.887	<.001	.009	3	1
LARGE_INTESTINE	IFNA21 →	+0.022	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

SIGLEC12 by ASB18 expression — LUNG_SCLC

Explore this box plot interactively →