ASB16

Across TCGA patient cohorts, ASB16 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASB16-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and EGFR_pY1068. Each is linked with ASB16 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASB16-to-partner and partner-to-ASB16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ASB16-low versus ASB16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASB16→partner) and Y-score (partner→ASB16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.774	-2.906	<.001	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.904	+2.479	<.001	.010	3	2
UCEC	EGFR_pY1068 →	-0.262	-2.222	.014	.011	3	1
UCEC	eIF4E →	+0.190	+2.906	.034	.001	3	1
UCEC	A-Raf_pS299 →	-0.114	-3.169	.024	.019	3	1
UCEC	Fibronectin →	-0.283	-2.222	.043	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

ATM by ASB16 expression — UCEC

Explore this box plot interactively →