Across TCGA pan-cancer cohorts, ASB15-AS1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of ASB15-AS1’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where ASB15-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types ASB15-AS1 is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.
KIRP, KIRC, and HNSC are the cancer types where ASB15-AS1 tumor–normal differential expression is most reproducible.