Across TCGA patient cohorts, ASB12 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASB12-associated genes across cancer lineages are eIF4E, MEK1, and Caspase-7-cleavedD198. Each is linked with ASB12 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASB12-to-partner and partner-to-ASB12 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASB12→partner) and Y-score (partner→ASB12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.160	+2.584	.048	.010	3	2
UCEC	MEK1 →	+0.371	+3.321	.008	.009	3	2
UCEC	Caspase-7-cleavedD198 →	+0.973	+3.700	<.001	.001	3	2
UCEC	IGFBP2 →	-0.829	-1.700	<.001	.042	3	1
UCEC	MSH2 →	-0.256	-2.089	.003	.016	3	1
UCEC	MSH6 →	-0.249	-3.169	.049	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration

ASB12 survival (RNA) · tumor vs normal (RNA) · all ASB12 data types