ASB11

Across TCGA patient cohorts, ASB11 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASB11-associated genes across cancer lineages are ATM, Rictor_pT1135, and Src. Each is linked with ASB11 in more than 2 cancer types. Because this analysis shows association rather than direction, both ASB11-to-partner and partner-to-ASB11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ASB11-low versus ASB11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASB11→partner) and Y-score (partner→ASB11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.578	-2.446	<.001	.018	3	3
UCEC	Rictor_pT1135 →	-0.111	-2.222	.003	.009	3	2
UCEC	Src →	-0.218	-1.700	.004	.042	3	2
UCEC	STAT3_pY705 →	-0.455	-2.405	<.001	.003	3	2
UCEC	eIF4E →	+0.217	+2.169	.006	.003	3	1
UCEC	ERK2 →	+0.175	+2.000	.015	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

ATM by ASB11 expression — UCEC

Explore this box plot interactively →