ASB10

Across TCGA patient cohorts, ASB10 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASB10-associated genes across cancer lineages are p62 Lck ligand, Annexin-1, and Tuberin. Each is linked with ASB10 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASB10-to-partner and partner-to-ASB10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by ASB10-low versus ASB10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASB10→partner) and Y-score (partner→ASB10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.319	+3.807	.029	<.001	3	1
UCEC	Annexin-1 →	+0.484	+3.189	.041	.010	3	1
UCEC	Tuberin →	+0.315	+2.000	.009	.032	3	1
UCEC	Caspase-8 →	-0.224	-3.432	.048	.005	3	1
UCEC	MEK1 →	+0.448	+2.700	.006	.006	2	1
UCEC	BRD4 →	+0.286	+2.818	.033	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

p62 Lck ligand by ASB10 expression — UCEC

Explore this box plot interactively →