ASB1

Across TCGA pan-cancer cohorts, ASB1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of ASB1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where ASB1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ASB1 is over-expressed in tumor, although a few such as LUAD and HNSC show the opposite, repressed pattern.

LUAD, HNSC, and PDAC are the cancer types where ASB1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ASB1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	III,IV	−0.303	<.001	9	view →
HNSC	All	II,III,IV	−0.279	.005	6	view →
PDAC	Male	II,III,IV	+1.095	<.001	5	view →
CCRCC	All	All	+0.684	<.001	4	view →
LSCC	Male	All	−0.216	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

ASB1–LUAD

Open the LUAD breakdown →