ASAP3

Across TCGA patient cohorts, ASAP3 mutation is significantly associated with the RNA expression of many other genes, with 4,848 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASAP3-associated genes across cancer lineages are PIGF, SLC4A2, and FAM53C. Each is linked with ASAP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both ASAP3-to-partner and partner-to-ASAP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PIGF grouped by ASAP3-low versus ASAP3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASAP3→partner) and Y-score (partner→ASAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PIGF →	+0.391	+2.597	.001	.005	3	3
UCEC	SLC4A2 →	+0.521	+3.119	<.001	<.001	3	3
UCEC	FAM53C →	+0.475	+4.010	<.001	<.001	3	3
UCEC	ACBD5 →	+0.512	+2.016	<.001	.001	3	3
UCEC	RARS1 →	+0.385	+2.744	<.001	<.001	3	3
UCEC	DNAJB1 →	+0.496	+3.108	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,848 associations by consensus.

PIGF by ASAP3 expression — SKCM

Explore this box plot interactively →