ASAP3

Across TCGA cell cohorts, ASAP3 mutation is significantly associated with the mutation status of many other genes, with 3,277 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ASAP3-associated genes across cancer lineages are L1CAM, NUP188, and CBX2. Each is linked with ASAP3 in more than 3 cancer types. Because this analysis shows association rather than direction, both ASAP3-to-partner and partner-to-ASAP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, L1CAM grouped by ASAP3-low versus ASAP3-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASAP3→partner) and Y-score (partner→ASAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	L1CAM →	+4.614	+4.614	.006	.006	1	4
STOMACH	NUP188 →	+4.807	+4.807	.008	.008	1	4
SOFT_TISSUE	CBX2 →	+5.066	+4.502	.007	.007	1	4
SKIN	LGI2 →	+4.239	+5.053	.007	.007	1	4
BLOOD_Leukemia	EHBP1L1 →	+2.591	+3.263	.004	.004	1	4
BLOOD_Leukemia	PI4KA →	+2.728	+3.375	.003	.003	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,277 associations by consensus.

L1CAM by ASAP3 expression — CNS

Explore this box plot interactively →