ASAP2

Across TCGA patient cohorts, ASAP2 mutation is significantly associated with the RNA expression of many other genes, with 3,850 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASAP2-associated genes across cancer lineages are ALAS1, VPS18, and TUBG1. Each is linked with ASAP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ASAP2-to-partner and partner-to-ASAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ALAS1 grouped by ASAP2-low versus ASAP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASAP2→partner) and Y-score (partner→ASAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ALAS1 →	+0.521	+4.087	<.001	<.001	3	3
UCEC	VPS18 →	+0.519	+1.857	<.001	<.001	3	3
SKCM	TUBG1 →	+0.635	+2.497	<.001	.009	3	3
UCEC	TCF19 →	+0.626	+1.879	<.001	<.001	3	3
UCEC	VPS53 →	+0.345	+2.086	<.001	<.001	3	3
BRCA	RN7SL478P →	+0.215	+3.975	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,850 associations by consensus.

ALAS1 by ASAP2 expression — UCEC

Explore this box plot interactively →