ASAP2

Across TCGA cell cohorts, ASAP2 mutation is significantly associated with the RNA expression of many other genes, with 248 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ASAP2-associated genes across cancer lineages are ABRA, SLCO6A1, and PNLIP. Each is linked with ASAP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASAP2-to-partner and partner-to-ASAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ABRA grouped by ASAP2-low versus ASAP2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASAP2→partner) and Y-score (partner→ASAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ABRA →	+0.075	+4.196	<.001	.001	3	1
CNS	SLCO6A1 →	+0.106	+3.730	<.001	.002	3	1
LUNG_SCLC	PNLIP →	+0.145	+4.269	<.001	.005	3	1
LUNG_SCLC	OR2AJ1 →	+0.046	+4.817	<.001	.001	3	1
LUNG_SCLC	LIPN →	+0.065	+4.643	<.001	.004	3	1
UPPER_AERODIGESTIVE_TRACT	APOBEC1 →	+0.080	+4.510	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 248 associations by consensus.

ABRA by ASAP2 expression — CNS

Explore this box plot interactively →