ASAP1

Across TCGA patient cohorts, ASAP1 mutation is significantly associated with the RNA expression of many other genes, with 2,790 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASAP1-associated genes across cancer lineages are TMEM225, SYNJ1, and DONSON. Each is linked with ASAP1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ASAP1-to-partner and partner-to-ASAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM225 grouped by ASAP1-low versus ASAP1-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASAP1→partner) and Y-score (partner→ASAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	TMEM225 →	+0.114	+5.039	<.001	.008	3	3
UCEC	SYNJ1 →	+0.258	+1.668	.007	.003	3	3
UCEC	DONSON →	+0.366	+1.632	.002	<.001	3	3
UCEC	CHAF1B →	+0.378	+1.793	.006	.001	3	3
UCEC	ZNF367 →	+0.534	+1.632	<.001	<.001	3	3
UCEC	CEP295 →	+0.385	+2.102	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,790 associations by consensus.

TMEM225 by ASAP1 expression — READ

Explore this box plot interactively →