ASAP1

Across TCGA patient cohorts, ASAP1 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASAP1-associated genes across cancer lineages are 4E-BP1, Cyclin-B1, and Caveolin-1. Each is linked with ASAP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ASAP1-to-partner and partner-to-ASAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by ASAP1-low versus ASAP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASAP1→partner) and Y-score (partner→ASAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.258	+1.936	.001	.008	3	3
UCEC	Cyclin-B1 →	+0.616	+1.700	<.001	.001	3	3
STAD	Caveolin-1 →	-1.113	-3.169	.002	.019	3	2
LUAD	Chk1_pS345 →	+0.151	+2.820	.001	.035	3	2
UCEC	JNK2 →	+0.207	+1.700	<.001	.001	3	2
UCEC	MEK1 →	+0.306	+1.807	.006	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

4E-BP1 by ASAP1 expression — UCEC

Explore this box plot interactively →