Across TCGA patient cohorts, ASAH2 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASAH2-associated genes across cancer lineages are ERK2, Caspase-8, and PDCD4. Each is linked with ASAH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASAH2-to-partner and partner-to-ASAH2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASAH2→partner) and Y-score (partner→ASAH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ERK2 →	+0.180	+1.339	.007	.037	3	2
UCEC	Caspase-8 →	-0.298	-3.221	<.001	<.001	3	2
UCEC	PDCD4 →	-0.479	-2.459	.003	.018	3	2
UCEC	Annexin-1 →	+0.542	+2.242	.002	.005	3	2
UCEC	4E-BP1 →	+0.389	+3.807	<.001	<.001	3	2
UCEC	C-Raf →	+0.148	+1.678	.002	.021	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Exploration

ASAH2 survival (RNA) · tumor vs normal (RNA) · all ASAH2 data types