Across TCGA pan-cancer cohorts, AS3MT mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated AS3MT data layer compared with 26 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher AS3MT mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated AS3MT expression acts as an unfavorable survival marker, although some lineages such as COAD and LSCC show a favorable association.

COAD, HNSC, and LSCC are the cancer types where AS3MT mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	III,IV	1.000	0.623	.040	18	view →
HNSC	DFS	Quartile	II,III,IV	0.482	0.813	.003	11	view →
LSCC	DFS	Quartile	II,III,IV	0.887	0.186	.024	3	view →
CCRCC	DFS	Median	All	0.662	0.810	.028	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: AS3MT tumor-vs-normal RNA expression · all AS3MT data types