Across TCGA pan-cancer cohorts, AS3MT mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of AS3MT’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where AS3MT mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types AS3MT is over-expressed in tumor, although a few such as HNSC and CCRCC show the opposite, repressed pattern.

HNSC, CCRCC, and PDAC are the cancer types where AS3MT tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AS3MT mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	−0.558	<.001	11	view →
CCRCC	Male	All	−0.465	<.001	11	view →
PDAC	Female	All	−1.417	<.001	8	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: AS3MT RNA expression & survival · all AS3MT data types