Across TCGA cell cohorts, AS3MT mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AS3MT-associated genes across cancer lineages are BPIFB6, HSF5, and TECRL. Each is linked with AS3MT in more than 1 cancer types. Because this analysis shows association rather than direction, both AS3MT-to-partner and partner-to-AS3MT results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AS3MT→partner) and Y-score (partner→AS3MT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BPIFB6 →	+0.016	+4.022	<.001	.006	3	1
LARGE_INTESTINE	HSF5 →	+0.031	+4.000	.006	.004	3	1
LARGE_INTESTINE	TECRL →	+0.014	+3.977	<.001	.001	3	1
LARGE_INTESTINE	OR5V1 →	+0.006	+4.022	<.001	.006	3	1
LARGE_INTESTINE	NAA11 →	+0.359	+3.443	.004	.009	2	1
LARGE_INTESTINE	ABCB5 →	+0.065	+3.443	<.001	.009	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

AS3MT survival (RNA) · tumor vs normal (RNA) · all AS3MT data types