ARV1

Across TCGA patient cohorts, ARV1 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARV1-associated genes across cancer lineages are mTOR_pS2448, Shc_pY317, and PCNA. Each is linked with ARV1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARV1-to-partner and partner-to-ARV1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by ARV1-low versus ARV1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARV1→partner) and Y-score (partner→ARV1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.167	-3.169	.041	.020	3	1
UCEC	Shc_pY317 →	-0.245	-3.169	.003	.020	3	1
UCEC	PCNA →	+0.250	+3.169	.035	.020	2	1
UCEC	STAT3_pY705 →	-0.560	-2.990	<.001	.036	2	1
UCEC	Cyclin-B1 →	+0.773	+3.169	.012	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

mTOR_pS2448 by ARV1 expression — UCEC

Explore this box plot interactively →