ART5

Across TCGA patient cohorts, ART5 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ART5-associated genes across cancer lineages are 14-3-3_beta, eEF2, and eIF4E. Each is linked with ART5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ART5-to-partner and partner-to-ART5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by ART5-low versus ART5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ART5→partner) and Y-score (partner→ART5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.114	-2.973	.015	.035	3	1
UCEC	eEF2 →	+0.466	+2.584	.005	.011	3	1
UCEC	eIF4E →	+0.225	+3.321	.022	.010	2	2
UCEC	GATA6 →	-0.181	-2.577	.012	.011	3	1
UCEC	Ku80 →	+0.240	+2.598	.029	.006	3	1
UCEC	MEK1 →	+0.641	+3.700	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

14-3-3_beta by ART5 expression — UCEC

Explore this box plot interactively →