ART3

Across TCGA patient cohorts, ART3 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ART3-associated genes across cancer lineages are mTOR_pS2448, EGFR_pY1068, and JNK2. Each is linked with ART3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ART3-to-partner and partner-to-ART3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by ART3-low versus ART3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ART3→partner) and Y-score (partner→ART3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.139	-2.115	.032	.019	3	2
UCEC	EGFR_pY1068 →	-0.244	-3.169	.026	.018	3	1
UCEC	JNK2 →	+0.209	+3.469	.016	.002	3	1
UCEC	MEK1 →	+0.353	+3.321	.027	.010	3	1
UCEC	PCNA →	+0.266	+2.807	.004	.003	3	1
UCEC	PDCD4 →	-0.600	-2.312	.003	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

mTOR_pS2448 by ART3 expression — UCEC

Explore this box plot interactively →