ARSL

Across TCGA patient cohorts, ARSL mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARSL-associated genes across cancer lineages are PTEN, STAT3_pY705, and Caspase-8. Each is linked with ARSL in more than 2 cancer types. Because this analysis shows association rather than direction, both ARSL-to-partner and partner-to-ARSL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTEN grouped by ARSL-low versus ARSL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARSL→partner) and Y-score (partner→ARSL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PTEN →	-0.293	-2.999	.045	.035	3	3
UCEC	STAT3_pY705 →	-0.376	-1.807	<.001	.024	3	3
UCEC	Caspase-8 →	-0.222	-2.295	.016	.005	3	3
UCEC	JNK_pT183_Y185 →	-0.165	-2.700	.007	.005	3	2
UCEC	Ku80 →	+0.185	+1.710	.033	.025	3	2
UCEC	mTOR_pS2448 →	-0.109	-1.680	.047	.042	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

PTEN by ARSL expression — UCEC

Explore this box plot interactively →