ARSL

Across TCGA cell cohorts, ARSL mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ARSL-associated genes across cancer lineages are SLC1A6, ARSH, and OR6J1. Each is linked with ARSL in more than 1 cancer types. Because this analysis shows association rather than direction, both ARSL-to-partner and partner-to-ARSL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC1A6 grouped by ARSL-low versus ARSL-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARSL→partner) and Y-score (partner→ARSL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SLC1A6 →	+0.042	+5.070	<.001	.001	3	1
BLOOD_Lymphoma	ARSH →	+0.035	+4.452	<.001	.001	3	1
BLOOD_Lymphoma	OR6J1 →	+0.003	+4.058	<.001	.009	3	1
LUNG_NSCLC_LUAD	CSN2 →	+0.019	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	MEIKIN →	+0.089	+4.887	.001	.009	3	1
LUNG_NSCLC_LUAD	C1orf232 →	+0.030	+4.887	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

SLC1A6 by ARSL expression — BLOOD_Lymphoma

Explore this box plot interactively →