Across TCGA patient cohorts, ARSI protein abundance is significantly associated with the RNA expression of many other genes, with 1,001 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible ARSI-associated genes across cancer lineages are ASPA, FAM13C, and ABI3BP. Each is linked with ARSI in more than 1 cancer types. Because this analysis shows association rather than direction, both ARSI-to-partner and partner-to-ARSI results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARSI→partner) and Y-score (partner→ARSI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ASPA →	+0.759	+0.797	<.001	<.001	3	2
LSCC	FAM13C →	+0.594	+0.650	.004	.005	3	2
LUAD	ABI3BP →	+1.073	+0.722	.002	.001	3	2
LUAD	ABCA9 →	+0.789	+0.725	.001	<.001	3	2
LUAD	ABCA6 →	+0.812	+0.652	.001	<.001	3	2
LSCC	PTH1R →	+0.714	+0.623	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,001 associations by consensus.

Exploration

ARSI survival (RNA) · tumor vs normal (RNA) · all ARSI data types